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NCL-L Rev D
General Overview
The CD33 molecule is the smallest member of the structurally related group of IgSF domain-
containing sialic acid binding proteins called the sialoadhesin family. CD33 antigen is reported
to be absent from pluripotential stem cells but appears on the myelomonocytic precursors after
CD34 antigen. It then continues to be expressed on both the myeloid and monocyte lineages,
although it is reported to be absent on granulocytes.
General References
Bradshaw EM, Chibnik LB, Keenan BT, et al. Nature Neuroscience. 2013, 16(7): 848 – 852.
Hoyer JD, Grogg KL, Hanson CA, et al. American Journal of Clinical Pathology. 2008; 129(2): 316 – 323.